Banca de QUALIFICAÇÃO: OPEYEMI BARNABAS AKINNIBI

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE: OPEYEMI BARNABAS AKINNIBI
DATA: 25/07/2025
HORA: 09:00
LOCAL: on line
TÍTULO:

Development and Evaluation of (-)-α-Bisabolol-Enriched Chitosan/Cellulose Nanofiber Hybrid Hydrogels: Physicochemical, Biomedical, and Biocompatibility Assessment for Potential Wound Healing / Skin Regeneration Applications

PALAVRAS-CHAVES:

Hydrogels; Biopolymer; (-)-α-Bisabolol; Antibacterial activity; Wound healing

PÁGINAS: 90
GRANDE ÁREA: Ciências Agrárias
ÁREA: Recursos Florestais e Engenharia Florestal
SUBÁREA: Tecnologia e Utilização de Produtos Florestais
ESPECIALIDADE: Tecnologia de Celulose e Papel
RESUMO:

Wound healing is a complicated biological process often disrupted by infection, dehydration, and

limited cell growth. A moist environment, infection prevention, and biocompatibility are all

required. Chitosan (CS) and cellulose nanofibers (CNF) are natural biopolymers known for their

biocompatibility, biodegradability, with the ability to create considerable stable hydrogel

matrices. α-Bisabolol (BIS), a naturally occurring sesquiterpene alcohol, has been reported as a

strong anti-inflammatory and antimicrobial agent. This enables it as a promising option for

wound treatment. In this study, α-bisabolol-enriched chitosan/cellulose nanofiber hybrid

hydrogel membranes were formulated using a physical freeze-thaw gelation method. Varying

concentrations of α-bisabolol oil were incorporated, which were stabilized by Tween 80. The

Surface morphology was examined using scanning electron microscopy (SEM), atomic force

microscopy (AFM), and optical microscopy. Moisture retention tests indicated that all

membranes kept up to 89% moisture retention ability. The swelling behavior indicated that all

samples absorbed a lot of water up to 10 times of initial weight. The formulated hydrogels have

considerable inhibitory zones against Escherichia coli (E. coli) and Staphylococcus aureus (S.

aureus). These results imply that CS/CNF hydrogels with α-bisabolol oil are promising

candidates for wound dressings. They offer moisture maintenance, mechanical stability, and

bioactive advantages that are vital for effective skin regeneration and healing.

MEMBROS DA BANCA:
Presidente - GUSTAVO HENRIQUE DENZIN TONOLI (Membro)
Interno - ALINE DE FÁTIMA SILVA LAGO - UFLA (Suplente)
Interno - JULIO CESAR UGUCIONI (Membro)
Interno - SAULO ROCHA FERREIRA (Membro)
Externo à Instituição - MARIANA APARECIDA BRAGA NASCIMENTO - UFLA (Suplente)
Externo à Instituição - SERGIY KYRYLENKO (MEDICAL INSTITUTE OF SUMY STATE UNIVERSITY, UKRAINE) - UFLA (Membro)