FUNGICIDES RESISTANCE: IMPLICATIONS ON PATHOGENS POPULATION BIOLOGICAL PROCESS
fungicide resistance
The architecture of most agroecosystems is composed of planted monocultures, whose plants are cultivated in high density and on large spatial scales. It may result in the emergence, adaptive evolution, and dissemination of pathogens, contributing to the accumulation of large populations of pathogens. Although fungicides are indispensable for high-quality crops, the rapid emergence and evolution of fungicide resistance have become the most important issue in modern agriculture. Thus, the sustainability and profitability of agricultural production have been challenged due to the limited number of chemical classes of fungicides. Fungicide resistance has principally been linked to three general mechanisms: non-synonymous mutations in the target genes of fungicide, target gene overexpression, and efflux pump upregulation. These mechanisms change either the structure or the expression level affecting the fungicide efficacy and resulting in different and varying resistance levels. In this review, our purpose is to do a more detailed discussion about point mutations at the target site of QoIs, MBCs, DMIs, and SDHIs due to the small numbers of resistant species for other fungicide classes. Moreover, we focus on non-target site mechanisms, such as overexpression of drug efflux pumps, detoxification, and CYP51 paralogs correlated with fungicide resistance. Understanding these mechanisms can facilitate the monitoring of resistance and assist in developing anti-resistance strategies and new fungicides molecules.