Sybthesis and characterization of natural biopolymers-based membranes functionalized with native Brazilian plant extracts for biomedical applications.
chitosan, cellulose nanofibrils, nanocellulose, tannins, films
Wound healing is a complex biological process that occurs naturally but often becomes impaired in conditions such as advanced age and diabetes. Effective healing requires adequate transport of nutrients, oxygen, and moisture to the wound bed. For centuries, medicinal plants have been used in wound management, initially in their raw form and later incorporated into advanced biomaterials to enhance therapeutic efficacy.
Mimosa Tenuiflora (MT), commonly known as jurema-preta and native to South and Central America, has attracted significant attention due to its angiogenic and cicatrizing properties. Previous studies attribute these biological activities primarily to the presence of tannins and saponins in the bark extract.
In the present research, hydrogel membranes were synthesized using cellulose nanofibrils (CNF), chitosan, and MT bark extract to develop a bioactive wound dressing material. The resulting membranes were extensively characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), swelling analysis, contact angle measurements, rheological testing, Thermogravimetric Analysis (TGA), Anti-bacterial analysis and CAM Assay.
The findings indicate that the incorporation of MT extract enhances the physicochemical and functional properties of CNF–chitosan membranes, suggesting their promising potential for biomedical applications, particularly in wound healing and tissue regeneration.