Resistance training and bone mineral density in rodent models of menopause: review and meta-analysis
resistance training; animal models; systematic review
The decline in bone mineral density (BMD) is common among older adults, especially due to reduced sex hormones production in women (menopause). Understanding the impact of resistance training on bone tissue is essential for developing effective strategies for the prevention and treatment of this condition. We investigated the effects of resistance training on BMD in rodent models of osteopenia induced by ovariectomy (OVX). The protocol was registered on PROSPERO (CRD42024549460). Inclusion criteria focused on OVX female rats and mice engaged in resistance training, with no restrictions on duration, frequency, or intensity. A comprehensive search across six databases (and grey literature) identified 314 articles, of which 18 were selected for evaluation. Resistance training, compared to control groups, significantly increased BMD, particularly in the femur and tibia. The included studies employed various training protocols, such as climbing, jumping, and squatting, with variations in training duration and intensity. The meta-analysis showed a standardized mean difference (SMD) of 3.02 (95% CI: 1.81–4.24) for climbing protocols and 1.27 (95% CI: 0.72–1.82) for jumping, indicating significant improvements in BMD, particularly in the femur and tibia. These findings suggest that resistance training positively impacts bone remodelling and may help restore bone microarchitecture in postmenopausal conditions.